特異性：Integrin beta 4 chain (CD104), Mr 200 kDa CD104 represents the integrin beta 4 subunit that associates non-covalently with integrin alpha 6 (CD49f) to form the alpha 6 beta 4 integrin heterodimer.2, 3 The alpha 6 beta 4 complex is expressed on the basal surface of a variety of epithelial cell types, particularly on stratified squamous epithelia. It is also found in peripheral nerves, in certain subsets of endothelial cells, and on immature thymocytes, and has been found to be associated with a number of malignant tissues.3-5, 6 Hemidesmosomal alpha 6 beta 4 plays an important role in the adhesion of epithelial cells to basement membranes via interactions with laminin and/or kalinin anchoring filaments.7 It is not known if the monoclonal antibody 346-11A can block this adhesion.
