86-0546-64　Cytochrome C (Mitochondrial Marker) Mouse Monoclonal Antibody 0.02 mg (With BSA & Azide at 0.2mg/mL)　MBS438650

仕様

• サイズ：0.02 mg (With BSA & Azide at 0.2mg/mL)
• 遺伝子名：[CYCS]
• クローナリティ：Monoclonal
• アイソタイプ：IgG2b, kappa
• クローン名：[CTC05]
• ホスト：Mouse
• 反応性：Human, Mouse, Rat, Horse, Dog, Pigeon, Frog, Drosophila. Others not known
• 特異性：Cytochrome C is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3.
• 形状：200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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