86-0534-38　Calcineurin A/PPP3CA 0.02 mg (With BSA & Azide at 0.2mg/mL)　MBS4380664

仕様

• サイズ：0.02 mg (With BSA & Azide at 0.2mg/mL)
• 遺伝子名：[PPP3CA]
• クローナリティ：Monoclonal
• アイソタイプ：IgG1
• クローン名：[CALNA/2353]
• ホスト：Mouse
• 反応性：Human. Others not known.
• 特異性：Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59kDa catalytic A subunit and a 19kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.
• 純度：Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• 形状：200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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