86-0532-99　SOX4 (Master Regulator of Epithelial-Mesenchymal Transition) 0.02 mg (With BSA & Azide at 0.2mg/mL)　MBS4380487

仕様

• サイズ：0.02 mg (With BSA & Azide at 0.2mg/mL)
• 遺伝子名：[SOX4]
• クローナリティ：Monoclonal
• アイソタイプ：IgG2b, kappa
• クローン名：[SOX4/2540]
• ホスト：Mouse
• 反応性：Human. Others not tested.
• 特異性：SOX4 is a member of the SOX (SRY-related HMG-box) family of transcription factors with a critical role in embryonic development and in cell-fate determination during organogenesis of the heart, pancreas, brain, and in B and T lymphocyte differentiation. SOX4 gene expression is upregulated in many cancer types, and increased SOX4 activity contributes to cellular transformation, cell survival, and metastasis. Gene expression profiling has uncovered SOX4 with upregulated activity during TGF-beta-induced epithelial-mesenchymal transition (EMT) in normal and cancerous breast epithelial cells. SOX4 is indispensable for EMT and cell survival in vitro and for primary tumor growth and metastasis in vivo. SOX4 is identified as a master regulator of EMT by governing the expression of the epigenetic modifier Ezh2.
• 形状：200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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