Form:Supplied as a liquid in PBS,, 1% BSA, 0.09% sodium azide.
Specificity:34betaE12 is specific for "high molecular weight" cytokeratins 1, 5, 10 and 14, corresponding to molecular weights 68, 58, 56.5 and 50kD, respectively, which are characteristically found in "complex" epithelium. The antibody reacts with all squamous and ductal epithelium as well as carcinomas such as squamous cell carcinoma and adenocarcinoma of ductal origin (e.g., breast, pancreas) but does not react with sarcoma, melanoma or lymphoma. This antibody reacts with benign small-acinar lesions of the prostate and has been shown to be useful as an adjunct in the identification of prostate carcinoma.
Clone # USB:34betaE12
Isotype:IgG1
Calc Applications Abbrev:IHC WB
Calc Crossreactivity:Hu
Immunogen:Keratin solubilized from human stratum corneum.