Form:Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with horseradish peroxidase (HRP).
Specificity:Recognizes human integrin alphaVbeta5. Does not recognize integrin alphaVbeta3 or alpha5beta1. Binds to the alphaVbeta5 complex. Has a Kd of 2.8nM in Mn2+, 4.0nM in Ca2+and 2.9nM in buffer lacking cation. Thus, cations do not significantly affect the binding to alphaVbeta5. Does not block ligand binding to purified alphaVbeta5, nor does it block cell adhesion mediated through this receptor.
Clone # USB:2Q873 (15F11)
Isotype:IgG2a
Calc Applications Abbrev:E IC IP
Calc Crossreactivity:Hu
Immunogen:Human integrin alphaVbeta5 purified from placental tissue and depleted of integrin alphaVbeta3.