Specificity:Recognizes native and denatured forms of human cathepsin L (25kD) and procathepsin L (42kD). Does not react with human cathepsin types B, D, H and S, procathepsins B and D, and procathepsin H, rat cathepsin B, and mouse procathepsins B and D. Species Crossreactivity: mouse procathepsin L (weak), rat cathepsin L (strong), and mink cathepsin and procathepsin L.
Clone # USB:8J540
Isotype:IgG1
Calc Applications Abbrev:E IHC WB
Calc Crossreactivity:Hu Mo Rt
Immunogen:Purified full length native protein (Human lung cancer line EPLC 32 M1). Epitope: Recognizes an epitope within amino acid residues GYGFEST (265-271 in procathepsin L and 169-175 in the mature cathepsin L molecule). Cellular Localization: Lysosomes.