Purity:Purified by Protein G affinity chromatography from culture supernatant.
Form:Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide.
Specificity:Has specificity for a conformation-dependent neoepitope that is expressed in activated protein C upon complex-formation with a1-antitrypsin. No reaction is seen to non-complexed a1-antitrypsin and only very little cross reaction to protein C zymogen. Note that specificity is calcium dependent.Reactivity: Reacts strongly with APC-AAT complexes in ELISA. It can be used in sandwich ELISA in combination with a polyclonal anti-protein C antiserum. Note that the conformational neoepitope expressed in the APC-AAT complex can also be expressed in APC coated directly onto a high-binding microtiter plate.
Clone # USB:7
Isotype:IgG1,k
Calc Applications Abbrev:E
Calc Crossreactivity:Hu
Immunogen:Recombinant form of human activated protein C (Drotrecogin alfa, Xigris)