Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a lyophilized powder from PBS, pH 7.2, 0.09% sodium azide, 1% BSA. Labeled with R. Phycoerythrin (RPE). Reconstitute with 1ml sterile 40-50% glycerol, ddH2O.
Specificity：3H1058 was clustered at the Fourth International Workshop on Leucocyte Differentiation Antigen (code number N221) as recognizing the CD18 antigen. The CD18 antigen is an integral membrane glycoprotein of 95kD molecular weight-known as the b chain, of the LFA-1 complex. The CD18 antigen is non-covalently linked to CD11a, b, c molecules. The main cellular reactivity of antibody YFC 118.3 is a strong reactivity with Leucocytes (platelets negative).The CD18 molecule is the receptor for ICAM-1 and is thus important for cell adhesion. 3H1058 blocks homotypic adhesion and other lymphocyte functions which involve the LFA-1 antigen. Species Crossreactivity: Clone is reported to crossreact with canine (3).
