Purity：Purified by Protein G affinity chromatography from tissue culture supernatant.
Form：Supplied as a liquid in PBS, pH 7.4, 1% BSA, 0.09% sodium azide.
Specificity：Recognizes CD49F (VLA-6 alpha chain), a 120kD cell surface glycoprotein. Reacts with platelets, megakaryocytes, T lymphocytes and common Acute Lymphoblastic Leukaemia cells (alpha-6 beta-1). In Immunohistochemistry reacts with epithelial cells of a variety of tissues, peripheral nerves, microvascular endothelial cells, placenta cyto- and syncytotrophoblasts. VLA-6 is an important mediator of cell binding to laminin. Studies suggest that clone GoH3 specifically blocks the binding of cells to the E8 fragment of laminin (7). Species Crossreactivity: Reported to react with Cynomolgus monkey (8), mouse, canine (5) and human.
