Specificity:Recognizes 2-3 disaccharide units on both skeletal (type II) and corneal (type I) keratan sulfate chains either in isolated or proteoglycan-bound form. The epitope is resistant to proteolytic or alkaline cleavages and is partially sensitive to keratanase or other endo-b-galactosidase treatment. Species Crossreactivity: human, bovine, sheep, porcine, canine and mouse (adult). No crossreactivity with chicken limb bud proteoglycans, dermatan sulfate proteoglycans of cartilage and proteoglycans of rat chondrosarcomas.
Clone # USB:2Q544
Isotype:IgG2b
Calc Applications Abbrev:E RIA WB
Calc Crossreactivity:Bo Ca Hu Mo Po Sh
Immunogen:Human articular cartilage proteoglycan digested with chondroitinase ABC.