85-7211-61　Hepatitis B Surface Antigen (HBsAg) 500ug　H1910-24A

特徴

• Hepatitis B is an infection of the liver caused by the hepatitis B virus.
• Approximately 5-10% of adults and 90% of babies who are infected with HBV will go on to carry the virus for the rest of their lives.
• These people will pass the virus onto others.
• HBV is excreted in body fluids such as semen, saliva, blood and urine in persons with acute or chronic infection.
• The route of transmission can include homosexual or heterosexual activity, blood-borne exposure (needles, transfusion), mother-infant, close personal contact and even by consuming contaminated food or water.
• Thus, Hepatitis B has become a major public health concern.
• When HBV invades the body it causes liver damage through induction of auto-immunity.
• Liver cell injury results from cytotoxic T cell activity rather than viral cytotoxic activity.
• The principal screening test for detecting current (acute or chronic) HBV infection is the identification of HBsAg, an envelope lipoprotein.
• This is the first immunological marker to appear in a patient’s serum and exist in high quantities in the blood.
• Patients who are HBsAg positive develop chronic persistent hepatitis (CPH) and chronic active hepatitis (CAH).
• Patients with CPH usually remain in good health.
• Those with CAH have progressive liver damage with the outcome being portal fibrosis, cirrhosis, or hepatocellular carcinoma.
• Screening for HBsAg is recommended for all donors, pregnant women and those individuals who at high risk.
• Presence of this marker is conclusive proof of HBV infection.
• Applications:Suitable for use in ELISA and Immunohistochemistry.
• Other applications have not been tested.
• Recommended Dilution:Immunohistochemistry: Paraffin tissue sections.
• No pretreatment required.
• Optimal dilutions to be determined by the researcher.
• Recommended Pair:Suitable for use as the capture or solid phase antibody.
• Matched to H1910-24 as the detection or conjugate (label) antibody.
• Affinity Constant:2x10e10 L/mole
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.