85-7211-29　C-Reactive Protein (CRP, PTX 1, PTX1) 250ug　C7907-09

特徴

• C-reactive protein (CRP) is an acute phase reactant.
• CRP is released by the body in response to acute injury, infection, or other inflammatory stimuli.
• Recent development of a high sensitivity assay for CRP (hs-CRP) has enabled investigation of this marker of systemic inflammation.
• CRP and Atherosclerosis:Atheromatous plaques in diseased arteries typically contain inflammatory cells.
• Rupture of atheromatous plaque is thought to be the mechanism for acute myocardial infarction and acute coronary syndrome.
• The most common site of plaque rupture appears to be the shoulder region where inflammatory cells are most prominent.
• Thus the release of acute phase reactants as a response to inflammation have been proposed as a potential marker of an "unstable" atheromatous plaque and underlying atherosclerosis.
• Studies have shown a positive association between CRP and coronary artery disease.
• In a survey of 388 British men aged 50-69, the prevalence of coronary artery disease increased 1.5 fold for each doubling of CRP level (1).
• Multiple prospective studies demonstrated that baseline CRP is a good marker of future cardiovascular events (2).
• It has been suggested that CRP may be a good marker of cardiovascular risk in addition to lipid level.
• Applications:Suitable for use in CRP immunoassay and immunoaffinity purification, and as coating/tracer antibody in ELISA.
• Other applications have not been tested.
• Recommended Dilution:ELISA: > 10e-6 (Titer)
• Optimal dilutions to be determined by the researcher.
• Hybridoma:Sp 2/0 myeloma cells with spleen cells from Balb/c mice.
• Matched Pair:Capture Antibody: C7907-09
• Detection Antibody: C7907-04Q
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.