CD71, a type II transmembrane glycoprotein expressed on the cell surface as a homodimer, is the transferrin receptor.
It is essential for the growth of normal and neoplastic cells (1, 4).
It is expressed at low levels on resting B and T lymphocytes but is upregulated during responses to antigens and mitogens, presumably reflecting the iron dependence of proliferation (4).
Its expression declines with maturation and differentiation.
CD71 plays a critical role in cell proliferation by controlling the supply of iron, which is essential for many metabolic pathways, through the binding and endocytosis of transferrin, the major iron- carrying protein.
It may also be involved in signal transduction via its association with the T cell receptor zeta chain.
Applicatons:Suitable for use in Immunoprecipitation, Immunohistochemistry and Flow Cytometry.
Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
Aliquots are stable at -20°C for 12 months after receipt.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：500ug
Host：rat
Source Antibody：mouse
Grade：Purified
Purity：Purified
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Labeled with Biotin.
Specificity：Recognizes the mouse transferrin receptor protein, Mr 180-190kD (90-95kD under reducing conditions).
