CD41 is the integrin alpha IIb chain, also called gpIIb, which is non-covalently associated with the integrin beta 3 chain, also called gpIIIa (CD61), forming the gpIIbIIIa complex.
Antibody reacts specifically with normal platelets and megakaryocytes but studies have shown that it does not react with Glanzmann’s thrombasthenic platelets which lack the membrane glycoprotein gpllbllla.
Does not inhibit the platelet aggregation and secretion induced by collagen, arachidonic acid and thrombin.
Does not inhibit the fibrinogen binding to human platelets induced by ADP, arachidonic acid and PAF.
Applications:Suitable for use in Flow Cytometry and in the identification of platelets and megakaryocytes.
Optimal dilutions to be determined by the researcher.
Source:Cell culture
Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
Aliquots are stable at -20°C for 12 months after receipt.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
Caution: FITC conjugates are sensitive to light.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ug
Host：mouse
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 1% BSA, 0.09% sodium azide. Labeled with Fluorescein Isothiocyanate (FITC).
Specificity：Recognizes an epitope on the gpIIb/IIIa complex on the surface membrane of human platelets. Precipitates two bands under non-reducing conditions (Mr 110kD and 130kD).
