85-7209-89　［取扱停止］Hepatitis B Surface Antigen, ad (HBsAg) 1mg　H1909-26

特徴

• Hepatitis B is an infection of the liver caused by the hepatitis B virus.
• Approximately 5-10% of adults and 90% of babies who are infected with HBV will go on to carry the virus for the rest of their lives.
• These people will pass the virus onto others.
• HBV is excreted in body fluids such as semen, saliva, blood and urine in persons with acute or chronic infection.
• The route of transmission can include homosexual or heterosexual activity, blood-borne exposure (needles, transfusion), mother-infant, close personal contact and even by consuming contaminated food or water.
• Thus, Hepatitis B has become a major public health concern.
• When HBV invades the body it causes liver damage through induction of auto-immunity.
• Liver cell injury results from cytotoxic T cell activity rather than viral cytotoxic activity.
• The principal screening test for detecting current (acute or chronic) HBV infection is the identification of HBsAg, an envelope lipoprotein.
• This is the first immunological marker to appear in a patient’s serum and exist in high quantities in the blood.
• Patients who are HBsAg positive develop chronic persistent hepatitis (CPH) and chronic active hepatitis (CAH).
• Patients with CPH usually remain in good health.
• Those with CAH have progressive liver damage with the outcome being portal fibrosis, cirrhosis, or hepatocellular carcinoma.
• Screening for HBsAg is recommended for all donors, pregnant women and those individuals who at high risk.
• Presence of this marker is conclusive proof of HBV infection.
• Applications:Suitable for use in ELISA.
• Other applications not tested.
• Recommended Dilutions:Optimal dilutions to be determined by the researcher.
• Hybridoma:Hybridization of P3X63-Ag8.653 myeloma cells with spleen cells from Balb/c mice.
• Affinity Constant: 1x10e10
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.