MMPs are a group of enzymes thought to be responsible for both normal connective tissue matrix remodelling and accelerated breakdown associated with neoplasm development.
MMP activity is modulated by tissue inhibitors of metalloproteinases (TIMP).
Imbalanced secretion of certain MMP or disturbances in the differential control of MMP by TIMP have been implicated in the invasive potential of malignant tumors.
MMPs and TIMPs play a significant role in regulating angiogenesis, the process of new blood vessel formation.
Ab is the preferred Ab for sensitive detection of MMP-9.
Positive Control: Conditioned, serum-free medium from (TPA-treated) human fibrosarcoma HT-1080 or endothelial HUVEC cells.
Applications and Suggested Dilutions:ELISA (For coating, order Ab without BSA)
Immunofluorescence
Cellular Localization: Cytoplasmic
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：500ul
Host：mouse
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 10mM PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide.
Specificity：Recognizes human pro (latent) and activated forms of matrix metalloproteinase 9 (MMP-9; also known as 92kD collagenase IV or gelatinase B).
