CD36 (also known as platelet glycoprotein IV, OKM5-antigen, or platelet glycoprotein IIIb) acts as a receptor for thrombospondin (TSP), collagen, falciparum malaria parasitized erythrocytes, and sickle erythrocytes.
It also functions as a scavenger receptor, mediating macrophage uptake of oxidized low density lipoprotein (LDL), and apoptotic polymorphonuclear leukocytes (PMN).
CD36 plays a role in platelet aggregation, macrophage foam cell development, inflammation, and the tissue ischaemia observed in sickle cell disease and cerebral malaria.
Applications:Suitable for use in Function Blocking, Flow Cytometry, Immunofluorescence, and Immunohistochemistry.
Not suitable for use in Western Blot.
Other applications have not been tested.
Recommended Dilution:Function Blocking: Order C2388-15X.
Immunohistochemistry: Frozen
Optimal dilutions to be determined by the researcher.
Positive Control:Tonsil
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：500ul
Host：mouse
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in 10mM PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide. Also available without BSA and azide, See C2388-15X.
Specificity：Recognizes human CD36 (MW: 88kD). Blocks adhesion of P. falciparum parasitized red blood cells to CD36. Strongly inhibits collagen-induced platelet aggregation.
Clone # USB：0.N.107 (185-1G2)
Isotype：IgG2a,k
Calc Applications Abbrev：FC IF IHC
Calc Crossreactivity：Hu
Immunogen：Stimulated human leukocytes. Cellular Localization: cell membrane
