Amyloid beta-protein/amyloid A4 or amyloid beta-peptide is derived from the amyloid beta-precursor protein.
Beta amyloid is an extracellular filamentous protein deposit found in the
brain.
It is the major protein component of amyloid cores, neuritic plaques and is also found as a deposit in neurofibrillary tangles.
In man, Alzheimer’s disease is the most common cause of senile dementia and is characterized by abnormal filamentous protein deposits in the brain.
Beta amyloid deposits are also detected in Lewy body dementia, Down’s syndrome, amyloidosis (Dutch type) and in the Guam
Parkinson-Dementia complex.
Applications:Suitable for use in Immunohistochemistry.
Other applications have not been tested.
Recommended Dilution:Immunohistochemistry (formalin/paraffin only): 1:25-1:50 for 60 min at RT.
Note: Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 min., followed by cooling at RT for 20 min.
Optimal dilutions to be determined by the researcher.
Positive Control:Human brain of Alzheimer’s disease.
Cellular Localization:Transmembrane (APP) and extracellular (amyloid b).
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：500ul
Host：mouse
Source Antibody：human
Grade：Supernatant
Purity：Tissue culture supernatant
Form：Supplied as liquid in 0.09% sodium azide.
Specificity：Recognizes a human 4-5kD peptide derived from the amyloid beta-precursor protein.
Clone # USB：0.N.28 (BAM01)
Isotype：IgG1,k
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to residues 8-17 (SGYEVHHQKL) of the amyloid beta-protein/amyloid A4 which is the same as aa660-669 of human amyloid A4/amyloid b protein precursor.
