85-7206-96　Fas (CD95, APO-1) 100ug　F0019-60B

特徴

• Apoptosis or programmed-cell death is a physiological process essential for the normal development and maintenance of homeostasis in many organisms.
• This “cellular suicide” can be mediated by the Fas antigen (CD95, APO1), a cell-surface glycoprotein, 40-50kD, that belongs to the nerve growth factor/tumor necrosis factor (TNF) receptor family.
• Mice carrying the lymphoproliferation (lpr) mutation, which develop lymphoadenopathy and suffer from a systematic lupus erythematosus-like autoimmune disease, have defects in the Fas gene.
• Fas is expressed in several tissues including blood, where it expression is upregulated on activated T and B lymphocytes and natural killer cells.
• Binding of the Fas antigen by agonistic anti-Fas antibody has been shown to induce apoptosis.
• Applications:Suitable for use in Immunoprecipitation, ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:Immunoprecipitation: 2-5ug/10e6 cells
• Western Blot: 1:500
• ELISA: 1:500
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• For long-term storage, store at -20°C.
• Aliquots are stable for at least 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.