Clusterin, which is also known as Sulfated Glycoprotein-2 (SGP-2), Dimeric Acidic Glycoprotein (DAG), and Testosterone Repressed Prostate Message-2 (TRPM-2), is a disulfide-linked heterodimeric sulfated glycoprotein expressed in a variety of tissues.
Although its function is unknown, clusterin binds to cells, membranes, and hydrophobic proteins.
It also inhibits complement activation.
Induced or elevated levels of clusterin have been associated with programmed cell death caused by hormonal stimuli or traumatic insult.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilutions:Western Blot: 0.5-2ug/ml.
Detects human clusterin a chain (40kD) in RIPA lysates from HeLa cells, human serum and MCF-7 cell lysates.
Immunohistochemistry: 5ug/ml (Paraffin embedded human brain sections).