85-7206-38　Tau (Tau Protein, Microtubule-associated Protein, MAP) 200ug　T1030

特徴

• Tau is a heterogeneous group of proteins that range in molecular weight from 50-67kD.
• They are instumental in the assembly of microtubules and have been associated with some disease states.
• In normal brain, tau is localized in the axons of the neurons but in some neuropathological lesions, it accumulates within the body of the neuron.
• Tau protein is a microtubule-associated protein predominantly localized to neuronal axons.
• Tau promotes tubulin polymerization and the stabilization of microtubules.
• In vivo this protein is enriched in the exonal compartment of neurons wherer it has a role in the rapid elongation of the axon.
• Hyperphosphorylated forms of Tau are the major components of paired helical filaments (PHF) found in the neurofibrillary tangles which characterize Alzheimer’s disease.
• Alternate splicing of tau mRNA, glycosylation, and differential phosphorylation contribute to the heterogeneity of tau.
• Applications:Suitable for use in ELISA, Western Blot and Immunhistochemsitry.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 0.5-2ug/ml detected tau proteins (50-70kD) in rat brain preparations.
• Immunohistochemistry: 20ug/ml detected tau proteins in rat brain sections.
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.