85-7206-08　［取扱停止］Fibroblast Growth Factor Receptor beta (Flg, FGFRb, FGFR1) 250ug　F4305-06

特徴

• The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution.
• FGFR family members differ from one another in their ligand affinities and tissue distribution.
• A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain.
• The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.
• This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction.
• Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2.
• Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
• Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized
• Applications:Suitable for use in Western Blot and Immunoprecipitation.
• Not suitable for use in Neutralization.
• Other applications have not been tested.
• Recommended Dilution:Western Blot: 2-5ug/ml detects recombinant FGF R-1 in sFGFR-1.
• Optimal diutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.