Insulin-like growth factor 1 (IGF-1) is involved in regulation of neuronal growth and development in central and peripheral nervous system.
It is known to protect neurons against cell death induced by amyloidogenic derivatives, glucose or serum deprivation through pathways involving AKT kinase and transcription factor FKHRL1 phosphorylation.
Activation of the insulin-like growth factor system has emerged as a key factor for tumor progression and resistance to apoptosis in many cancers like breast and thyroid cancers.
Neutralizes the biological activities of IGF-1 in vitro bioassays for insulin-like, mitogenic and sulfation activities.
Applications:Suitable for use in RIA and ELISA.
Other applications not tested.
Recommended Dilutions:Optimal dilutions to be determined by the researcher.
Source:Tissue culture supernatant
Affinity Constant:1x10e8-10e9 L/mole
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ug
Host：mouse
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Recognizes human IGF-1. Basic IGF-1-like forms (pI > 9.0) exhibit substantial crossreactivity. Crossreacts with IGF-2: 1%; Proinsulin: 1.4%; MSF: 1%; Insulin: < 0.1%. Species Crossreactivity: mouse and rat.
Clone # USB：0.B.16
Isotype：IgG1
Calc Applications Abbrev：E RIA
Calc Crossreactivity：Hu Mo Rt
Immunogen：Purified human IGF-1 conjugated to ovalbumin.
