Polypeptide hormones secreted by the parathyroid glands, which promote release of calcium from bone to extracellular fluid by activating osteoblasts and inhibiting osteoclasts, indirectly promote increased intestinal absorption of calcium and promote renal tubular reabsorption of calcium and increased renal excretion of phosphates.
It is a major regulator of bone metabolism.
Secretion of parathyroid hormone increases when the level of calcium in the extracellular fluid is low.
Its action is opposed by calcitonin.
Parathyroid hormone (PTH), or parathormone, is secreted by the parathyroid glands as a polypeptide containing 84 amino acids.
It acts to increase the concentration of calcium (Ca2+) in the blood, whereas calcitonin (a hormone produced by the parafollicular cells (C cells) of the thyroid gland) acts to decrease calcium concentration.
PTH acts to increase the concentration of calcium in the blood by acting upon parathyroid hormone receptor in three parts of the body.
PTH half-life is approximately 4 minutes.
Applications:Suitable for use in ELISA, Immunohistochemistry and RIA.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 month after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ug
Host：mouse
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Recognizes human 1-34 and 1-84 Parathyroid Hormone. Has not been cross-adsorbed and may crossreact with homologus proteins from related species.
Clone # USB：8.BG.10 (3H9)
Isotype：IgG2b
Calc Applications Abbrev：E IHC RIA
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa1-34 of mature human Parathyroid Hormone, conjugated to a carrier protein.
