85-7204-43　Dopamine Beta Hydroxylase (DBH, Dopamine beta Monooxygenase) 2ml　D9000-20

特徴

• The production of neurotransmitters is controlled by environmental stimuli, which send signals through second messengers and protein kinase pathways.
• Regulation of gene expression of dopamine beta hydroxylase and tyrosine hydroxylase, two of the catecholamine biosynthetic enzymes, by cyclic AMP, diacyl glycerol, and Ca2+ leads to increased neurotransmitter biosynthesis.
• Dopamine beta-hydroxylase catalyzes the conversion of dopamine to noradrenaline and is expressed selectively in noradrenergic and adrenergic neurons in the nervous system.
• The disruption of the DBH gene is thought to cause changes in development and behavior in certain models.
• Both DBH and the multiple regulatory pathways of DBH are of increasing research in many neurological diseases.
• Applications:Suitable for use in ELISA, Immunohistochemistry, Immunocytochemistry, Western Blot and Radial Immunodiffusion (RID).
• Antibody is successfully used for the co-location of nerve growth factor receptor and DBH immunoreactivity sites in rat skin.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: 1:30-1:50
• Immunocytochemistry: 1:30-1:50
• Optimal dilutions to be determined by the researcher.r.
• Storage and Stability:Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.