85-7203-25　［取扱停止］Dopamine (Catecholamine) 1mg　D9000

特徴

• Dopamine is an endogenous catecholamine that influences many cellular activities, including behavior, hormone synthesis and release, blood pressure and intracellular ion transport.
• A family of at least 5 Dopamine Receptors (DR) genes, D1-D5, have been identified based upon the amino acid identity, pharmacological specificity and effector responses.
• DR have been classified into either the D1-like (D1, D1B, and D5) or D2-like (D2, D3, and D4).
• The two isoforms of D2R, D2 long (D2L) and short (D2S), are encoded by splice variants of a single gene and differ only by the presence of an additional 29aa in the intracellular domain 3 of the D2 long form.
• It may play a role in the coupling of the receptor to G- proteins.
• All members of this family have similar structure and contain 7 putative transmembrane domains.
• A given cell or tissue may express more than one DR.
• Specific radioligands do not exist that can differentiate between these DR.
• Therefore, specific antibodies are needed to distinguish, localize and document changes in DR levels in cells and tissues under various normal and pathological conditions.
• Human D3 receptor is a 400aa, G-protein coupled and transmembrane receptor protein.
• Applications:Suitable for use in Immunocytochemistry.
• Other applications not tested.
• Recommended Dilutions:Immunocytochemistry: Visualization of catecholamine using secreting cells.
• Optimal dilutions to be determined by the researcher.
• Affinity Constant:~1x10e7L/mole
• Source: Ascites
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.