85-6830-89 Anti-Mouse Fas Ligand In Vivo Antibody - Low Endotoxin （MFL3） [ICH1178] 50mg ICH1178
![Anti-Mouse Fas Ligand In Vivo Antibody - Low Endotoxin （MFL3） [ICH1178] 50mg](https://aimg.as-1.co.jp/c/85/6830/89/85682291.jpg)
特徴
- 背景：FasL antibody, clone AFS98, recognizes Fas ligand (FasL), also known as CD178, Apo-1 ligand, and CD95 ligand. FasL is a 40 kDa type II integral membrane protein that belongs to the tumor necrosis factor (TNF) superfamily. FasL is expressed by activated T cells and natural killer (NK cells). Binding of FasL to its receptor Fas (CD95, APO-1) induces apoptotic cell death in Fas-expressing target cells, contributing to anti-viral immunity. FasL also contributes to peripheral tolerance and the downregulation of immune responses through activation-induced autocrine and paracrine T cell death. FasL is also found in the anterior chamber of the eye and on Sertoli cells in the testis, and is implicated in immune-privilege at these sites. FasL also contributes to CD8 proliferation and neutrophil recruitment. Soluble FasL (26 kDa) can be released following cleavage by metalloproteinases and block FasL-mediated signaling. Fas/FasL-signaling is involved in the development of many human diseases, including autoimmunity and cancer. Many human tumors over-express FasL, resulting in tumor infiltrating lymphocyte (TIL) apoptosis and immune evasion, which is associated with poor prognosis.
仕様
- サイズ：50mg
- ターゲット：Fas Ligand
- クローン：MFL3
- 免疫動物：Armenian Hamster
- 交差性：Mouse
- 精製方法：This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
- 抗原：B6 mouse FasL cDNA-transfected baby hamster kidney (B6 FasL/BHK) cells
- 濃度：≥ 5.0 mg/ml
- 構成：This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
- 純度：≥95% monomer by analytical SEC, >95% by SDS Page
- エンドトキシン：<1.0 EU/mg as determined by the LAL method
- Aggregation：Aggregation level ≤ 5%
- 適用：Blocking, Flow Cytometry, Immunofluorescence
- データシート：https://ichor.bio/product/anti-mouse-fas-ligand-in-vivo-antibody-low-endotoxin-mfl3-ich1178/?action=genpdf&id=80053
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