85-6830-10 Bulk anti-Human CD4 antibody （OKT-4） [ICH1166] 100mg ICH1166UL
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特徴
- 背景：Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.(Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1). Down-regulated by HIV-1 Vpu. Acts as a receptor for Human Herpes virus 7/HHV-7.
仕様
- サイズ：100mg
- ターゲット：CD4
- クローン：OKT-4
- 免疫動物：Mouse
- 交差性：Human, Rhesus, Cynomolgus, Chimpanzee, Sooty Mangabey
- 精製方法：This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
- 抗原：Human peripheral T cells
- 濃度：1.0 – 5.0 mg/ml
- 構成：This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (PBS) pH 7.2 - 7.4, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and azide free
- 純度：>98% by SDS-PAGE and HPLC
- エンドトキシン：≤ 0.75 EU/mg as determined by the LAL method
- Aggregation：Aggregation level ≤ 1%
- 適用：ELISA, ICC, IF Staining, IHC (Frozen), Immunoprecipitation, Neutralisation, Western Blot
- データシート：https://www.ichor.bio/product/anti-mouse-cd4-in-vivo-antibody-low-endotoxin-okt-4-ich1166/?action=genpdf&id=77225
- この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
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85-6830-07
Bulk anti-Human CD4 antibody （OKT-4） [ICH1166] 5mg
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85-6830-08
Bulk anti-Human CD4 antibody （OKT-4） [ICH1166] 25mg
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85-6830-09
Bulk anti-Human CD4 antibody （OKT-4） [ICH1166] 50mg
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85-6830-10
Bulk anti-Human CD4 antibody （OKT-4） [ICH1166] 100mg
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