85-6826-49 Anti-Mouse CD278 In Vivo Antibody - Low Endotoxin （7E.17G9） 50mg ICH1082
特徴
- 背景：Inducible co-stimulator (ICOS), also called ALIM and H4, is a homodimeric protein and member of the CD28 family of immune co-stimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS enhances all basic T cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B cells. Unlike the constitutively expressed CD28, ICOS has to be de novo induced on the T cell surface, does not up-regulate the production of IL-2, but superinduces the synthesis of IL-10, a B cell-differentiation factor. In vivo, ICOS is highly expressed on tonsillar T cells, which are closely associated with B cells in the apical light zone of germinal centres, the site of terminal B cell maturation. ICOS regulates CD28-dependent and CD28-independent CD4 (+) subset (Th1 and Th2) responses. It is a major regulator of the adaptive immune system and therefore, has a protective role in inflammatory autoimmune diseases.
仕様
- サイズ：50mg
- ターゲット：CD278
- クローン：7E.17G9
- 免疫動物：Rat
- 交差性：Mouse
- 精製方法：This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
- 濃度：1.0 - 5.0 mg/ml
- 構成：0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
- 純度：>95% by SDS-PAGE and HPLC
- エンドトキシン：≤ 1.0 EU/mg as determined by the LAL method
- Aggregation：Aggregation level ≤ 5%
- 適用：Western Blot, Blocking, Functional Assays, Flow Cytometry
- データシート：https://www.ichor.bio/product/Anti-CD278-In-Vivo-Antibody-Low-Endotoxin-7E.17G9-ICH1082?action=genpdf&id=66209
- この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）
- 【試薬に関するお問合せ】
- アズワン株式会社 試薬・プロセス材料グループ
- TEL：06-6447-8641
- FAX：06-6447-8642
- E-mail：[email protected]
商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
|
85-6826-48
Anti-Mouse CD278 In Vivo Antibody - Low Endotoxin （7E.17G9） 25mg
|
|
|
85-6826-50
Anti-Mouse CD278 In Vivo Antibody - Low Endotoxin （7E.17G9） 100mg
|
|
|
85-6826-49
Anti-Mouse CD278 In Vivo Antibody - Low Endotoxin （7E.17G9） 50mg
|
|
|
85-6826-47
Anti-Mouse CD278 In Vivo Antibody - Low Endotoxin （7E.17G9） 5mg
|
よくあるご質問（FAQ）
掲載カタログ情報
| 掲載カタログ名 | 掲載ページ |
|---|