85-6826-13 Anti-Mouse CD40 In Vivo Antibody - Low Endotoxin （FGK4.5） 50mg ICH1073
特徴
- 背景：CD40, also known as TNFSF5, is a type I transmembrane protein and member of the TNF receptor family. The binding of CD40L (CD40) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40 is expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40L is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to "immunodeficiency with hyper-IgM", a disease characterized by failure to produce IgG, IgA and IgE. Some of the early intracellular signaling by the CD4-CD40L system includes the association of the CD40 with TRAFs and the activation of various kinases (4). Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of CD4-CD40L is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.
仕様
- サイズ：50mg
- ターゲット：CD40
- クローン：FGK4.5
- 免疫動物：Rat
- 交差性：Mouse
- 精製方法：This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
- 抗原：Recombinant Mouse CD40 Fusion Protein
- 濃度：1.0 - 5.0 mg/ml
- 構成：0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added
- 純度：>95% by SDS-PAGE and HPLC
- エンドトキシン：<0.5 EU/mg as determined by the LAL method
- Aggregation：Aggregation level ≤ 5%
- 適用：Western Blot, Functional Assays, Flow Cytometry
- データシート：https://www.ichor.bio/product/Anti-CD154-In-Vivo-Antibody-Low-Endotoxin-FGK4.5-ICH1073?action=genpdf&id=66603
- この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
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85-6826-11
Anti-Mouse CD40 In Vivo Antibody - Low Endotoxin （FGK4.5） 5mg
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85-6826-14
Anti-Mouse CD40 In Vivo Antibody - Low Endotoxin （FGK4.5） 100mg
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85-6826-13
Anti-Mouse CD40 In Vivo Antibody - Low Endotoxin （FGK4.5） 50mg
|
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85-6826-12
Anti-Mouse CD40 In Vivo Antibody - Low Endotoxin （FGK4.5） 25mg
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