85-6826-08 Anti-Mouse CD120a In Vivo Antibody - Low Endotoxin (55R-593) [ICH1069] 25mg ICH1069
特徴
- 背景:Tumor Necrosis Factor Receptor Type I (TNFRI) is a 55kD Type I transmembrane protein. TNFRI is expressed independently of TNFRII at low levels on a wide variety of cell types. TNFRI binds TNF-A and TNF-B (also known as LT-A). The subsequent signaling is known to be important for inducing cytolytic activity, antiviral activity, expression of manganous superoxide dismutase and intercellular adhesion molecule (ICAM), IL-6 mRNA accumulation and NF-ĸB induction. TNFRI carries an approximately 80 amino acid death domain near its carboxy terminus capable of transmitting an apoptotic signal through its interaction with TRADD (TNF Receptor I associated death domain protein). Binding of 55R-170 antibody to TNFRI has been shown to block in vitro and in vivo receptor signaling initiated by ligand binding.
仕様
- サイズ:25mg
- ターゲット:CD120a
- クローン:55R-593
- 免疫動物:Armenian Hamster
- 交差性:Mouse
- 精製方法:This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
- 抗原:E. coli-expressed extracellular domain of the mouse TNFRI protein
- 濃度:1.0 mg/ml
- 構成:0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
- 純度:>95% by SDS-PAGE and HPLC
- エンドトキシン:≤ 1.0 EU/mg as determined by the LAL method
- Aggregation:Aggregation level ≤ 5%
- 適用:Immunoprecipitation, Western Blot
- データシート:https://ichor.bio/product/anti-cd120a-in-vivo-antibody-low-endotoxin-55r-593-ich1069/?action=genpdf&id=69753
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