特徴
- 背景：Interferon-gamma (IFN-gamma) exerts its biologic effects by interacting with a single high affinity receptor, IFN-gamma receptor. This receptor is present on almost all cell types except mature erythrocytes. The IFN-gamma receptor consists of two polypeptide chains alpha and beta and requires association of JAK1, JAK2 and Stat1 for IFN-gamma signal transduction. In signal transduction, IFN-gamma induces tyrosine phosphorylation of IFN-gamma receptor alpha (IFNGR1) leading to the formation of a docking site on the activated receptor for Stat1, which specifically activates IFN-gamma induced gene transcription. The IFN-gamma receptor is structurally related to the recently cloned IL-10 receptor. GIR 208 binds IFNGR1 and blocks binding of IFN-gamma to the receptor.
仕様
- サイズ：5mg
- ターゲット：CD119
- クローン：GIR 208
- 免疫動物：Mouse
- 交差性：Human
- 精製方法：This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
- 抗原：Human IFN-gamma R alpha, Purified from human placenta
- 濃度：1.0 - 5.0 mg/ml
- 構成：0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
- 純度：>98% by SDS-PAGE and HPLC
- エンドトキシン：≤ 0.75 EU/mg as determined by the LAL method
- Aggregation：Aggregation level ≤ 1%
- 適用：Immunoprecipitation, Western Blot, Blocking, Functional Assays
- データシート：https://www.ichor.bio/product/Anti-CD119-In-Vivo-Antibody-Low-Endotoxin-GIR-208-ICH1028?action=genpdf&id=69362
- この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）
- 【試薬に関するお問合せ】
- アズワン株式会社 試薬・プロセス材料グループ
- TEL：06-6447-8641
- FAX：06-6447-8642
- E-mail：[email protected]
商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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85-6824-15
Bulk anti-Human CD119 antibody （GIR 208） 50mg
|
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85-6824-13
Bulk anti-Human CD119 antibody （GIR 208） 5mg
|
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85-6824-14
Bulk anti-Human CD119 antibody （GIR 208） 25mg
|
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85-6824-16
Bulk anti-Human CD119 antibody （GIR 208） 100mg
|
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