85-6823-41　Bulk anti-Human CD28 antibody （CD28.2） 25mg　ICH1013UL

特徴

• 背景：CD28 (Cluster of Differentiation 28) is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. It is expressed on the cell surface as disulfide-linked homodimer or as monomer. CD28 is the receptor for B7.1 (CD80) and B7.2 (CD86). When activated by Toll-like receptor ligands, the B7.1 expression is upregulated in antigen presenting cells (APCs). The B7.2 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. Stimulation through CD28 in addition to the TCR can provide a potent co-stimulatory signal to T cells for the production of various interleukins (IL-2 and IL-6 in particular). CD28 possesses an intracellular domain with several residues that are critical for its effective signalling. CD28 also contains two proline-rich motifs that are able to bind SH3-containing proteins. CD28 has also been found to stimulate eosinophil granulocytes where its ligation with anti-CD28 leads to the release of IL-2, IL4, IL-13 and IFN-gamma

仕様

• サイズ：25mg
• ターゲット：CD28
• クローン：CD28.2
• 免疫動物：Mouse
• 交差性：Human
• 精製方法：This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
• 濃度：1.0 mg/ml
• 構成：0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
• 純度：>90% by SDS-PAGE and HPLC
• エンドトキシン：<0.1 EU/mg as determined by the LAL method
• Aggregation：Aggregation level ≤ 5%
• 適用：IHC (Frozen), Flow Cytometry, Functional Assays
• データシート：https://www.ichor.bio/product/Anti-CD28-In-Vivo-Antibody-Low-Endotoxin-CD28.2-ICH1013?action=genpdf&id=66589
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