85-6823-33　Bulk anti-Human CD20 antibody （2H7） 25mg　ICH1012UL

特徴

• 背景：The CD20 antigen, also called MS4A1, B1 and Bp35, is a non-glycosylated, transmembrane spanning, phosphoprotein. The CD20 protein is present on human pre B lymphocytes and on B lymphocytes at all stages of maturation, except on plasma cells, and is synchronous with the expression of surface IgM. It is also expressed in some follicular dendritic cells and at low levels on a T cell subset. CD20 has been shown to be heavily phosphorylated in activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn), and exists in a complex with MHC class I and II, CD53, CD81, and CD82. Extensive CD20 cross-linking may also influence cell death by apoptosis. Therapy with antibodies against CD20 is a widely used regimen in the treatment of all B cell lymphomas and leukemias.

仕様

• サイズ：25mg
• ターゲット：CD20
• クローン：2H7
• 免疫動物：Mouse
• 交差性：Human
• 精製方法：This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
• 濃度：1.0 - 5.0 mg/ml
• 構成：0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
• 純度：>98% by SDS-PAGE and HPLC
• エンドトキシン：≤ 0.75 EU/mg as determined by the LAL method
• Aggregation：Aggregation level ≤ 1%
• 適用：Flow Cytometry, CyTOF, IHC (Frozen), Immunoprecipitation
• データシート：https://www.ichor.bio/product/Anti-CD20-In-Vivo-Antibody-Low-Endotoxin-2H7-ICH1012?action=genpdf&id=65931
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