85-6650-30　XBP-1 Monoclonal Antibody 50ul　BT-MCA1306

特徴

• 背景：This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively e

仕様

• サイズ：50ul
• 抗原：Purified recombinant fragment of human XBP-1 expressed in E. Coli.
• 免疫動物：Mouse
• 交差性：Human
• 適用：WB, ELISA
• クラス：IgG
• クロナリティ：Monoclonal
• 濃度：1 mg/ml
• 別名：XBP1; TREB5; XBP2; X-box-binding protein 1; XBP-1; Tax-responsive element-binding protein 5
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