85-6650-01　UHRF1 Monoclonal Antibody 100ul　BT-MCA1267

特徴

• 背景：This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.

仕様

• サイズ：100ul
• 抗原：Purified recombinant human UHRF1 (N-terminus) protein fragments expressed in E.coli.
• 免疫動物：Mouse
• 交差性：Human
• 適用：WB, IF, ICC
• クラス：IgG
• クロナリティ：Monoclonal
• 濃度：1 mg/ml
• 別名：UHRF1; ICBP90; NP95; RNF106; E3 ubiquitin-protein ligase UHRF1; Inverted CCAAT box-binding protein of 90 kDa; Nuclear protein 95; Nuclear zinc finger protein Np95; HuNp95; hNp95; RING finger protein 106; Transcription factor ICBP90; Ubiquit
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