85-6648-15　TAB1 Monoclonal Antibody 100ul　BT-MCA1181

特徴

• 背景：The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced tr

仕様

• サイズ：100ul
• 抗原：Purified recombinant human TAB1 (N-terminus) protein fragments expressed in E.coli.
• 免疫動物：Mouse
• 交差性：Human,Mouse,Rat,Bovine,Dog,Pig
• 適用：WB
• クラス：IgG
• クロナリティ：Monoclonal
• 濃度：1 mg/ml
• 別名：TAB1; MAP3K7IP1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TGF-beta-activated kinase 1-binding protein 1; TAK1-binding protein 1
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