85-6610-45　DNA Ligase IV（Phospho Thr650） Polyclonal Antibody 100ul　BT-AP15251

特徴

• 背景：The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.

仕様

• サイズ：100ul
• 抗原：The antiserum was produced against synthesized peptide derived from human DNA Ligase 4 around the phosphorylation site of Thr650. AA range:616-665
• 免疫動物：Rabbit
• 交差性：Human, Rat, Mouse
• 適用：IHC-p, IF, ELISA
• クラス：IgG
• クロナリティ：Polyclonal
• 濃度：1 mg/ml
• 別名：DNA ligase 4; LIG4; DNA ligase 4; DNA ligase IV; Polydeoxyribonucleotide synthase [ATP; 4
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