85-6584-22　ASAP2 Polyclonal Antibody 20ul　BT-AP14340

特徴

• 背景：This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has Catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle

仕様

• サイズ：20ul
• 抗原：Synthesized peptide derived from human protein . at AA range: 640-720
• 免疫動物：Rabbit
• 交差性：Human, Mouse
• 適用：WB, ELISA
• クラス：IgG
• クロナリティ：Polyclonal
• 濃度：1 mg/ml
• 別名：Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 ;Development and differentiation-enhancing factor 2;Paxillin-associated protein with ARF GAP activity 3;PAG3;Pyk2 C-terminu
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