85-6579-67　Sgo1（Phospho Ser14） Polyclonal Antibody 20ul　BT-AP14171

特徴

• 背景：The protein encoded by this gene is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714). Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life (PMID:25282101). Fibro

仕様

• サイズ：20ul
• 抗原：The antiserum was produced against synthesized peptide derived from human SGO1 around the phosphorylation site of Ser14. AA range:1-50
• 免疫動物：Rabbit
• 交差性：Human, Rat, Mouse
• 適用：IHC-p, IF, ELISA
• クラス：IgG
• クロナリティ：Polyclonal
• 濃度：1 mg/ml
• 別名：Shugoshin-like 1; SGOL1; SGO1; Shugoshin-like 1; hSgo1; Serologically defined breast cancer antigen NY-BR-85
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