85-6549-06　PLB（Phospho Ser16/T17） Polyclonal Antibody 100ul　BT-AP13150

特徴

• 背景：The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.

仕様

• サイズ：100ul
• 抗原：The antiserum was produced against synthesized peptide derived from human PLB around the phosphorylation site of Ser16 and Thr17. AA range:1-50
• 免疫動物：Rabbit
• 交差性：Human, Mouse, Rat
• 適用：IF, ICC, ELISA
• クラス：IgG
• クロナリティ：Polyclonal
• 濃度：1 mg/ml
• 別名：Cardiac phospholamban; PLN; PLB; Cardiac phospholamban; PLB
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