85-6510-73　PEN2 Rabbit Polyclonal Antibody 20ul　BT-AP11874

特徴

• 背景：Presenilins| which are components of the gamma-secretase protein complex| are required for intramembranous processing of some type I transmembrane proteins| such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides| the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling| and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants.

仕様

• サイズ：20ul
• 抗原：Synthesized peptide derived from human PEN2
• 免疫動物：Rabbit
• 交差性：Human, Mouse, Rat
• 適用：IHC-p, IF
• クラス：IgG
• クロナリティ：Polyclonal
• 濃度：1 mg/ml
• 別名：PEN2
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