85-6494-26　MIB2 Polyclonal Antibody 100ul　BT-AP11327

特徴

• 背景：E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.,induction:Down-regulated in many primary skin melanomas. Treatment with a demethylating agent, 5'-aza-2-deoxycytidine, restores expression, suggesting that down-regulation is the result of methylation of the gene.,pathway:Protein modification; protein ubiquitination.,PTM:Ubiquitinated. Possibly via autoubiquitination.,Contains 1 ZZ-type zinc finger.,Contains 2 MIB/HERC2 domains.,Contains 2 RING-type zinc fingers.,Contains 9 ANK repeats.,subcellular location:Colocalizes with endosomal compartments.,subunit:Interacts with actin monomer.,tissue specificity:Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.,

仕様

• サイズ：100ul
• 抗原：Synthesized peptide derived from part region of human protein
• 免疫動物：Rabbit
• 交差性：Human, Mouse, Rat
• 適用：WB, ELISA
• クラス：IgG
• クロナリティ：Polyclonal
• 濃度：1 mg/ml
• 別名：E3 ubiquitin-protein ligase MIB2 ;EC 6.3.2.-;Mind bomb homolog 2;Novel zinc finger protein;Novelzin;Putative NF-kappa-B-activating protein 002N;Skeletrophin;Zinc finger ZZ type with ankyri
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