85-6490-22　MDC1（Phospho Ser513） Polyclonal Antibody 50ul　BT-AP11194

特徴

• 背景：The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.

仕様

• サイズ：50ul
• 抗原：The antiserum was produced against synthesized peptide derived from human MDC1 around the phosphorylation site of Ser513. AA range:479-528
• 免疫動物：Rabbit
• 交差性：Human, Rat, Mouse
• 適用：IHC-p, IF, ELISA
• クラス：IgG
• クロナリティ：Polyclonal
• 濃度：1 mg/ml
• 別名：Mediator of DNA damage checkpoint protein 1; MDC1; KIAA0170; NFBD1; Mediator of DNA damage checkpoint protein 1; Nuclear factor with BRCT domains 1
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