85-6446-53　ER alpha （Acetyl Lys303） Rabbit Polyclonal Antibody 50ul　BT-AP09746

特徴

• 背景：Composed of three domains: a modulating N-terminal domain| a DNA-binding domain and a C-terminal steroid-binding domain.|Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.|online information:Estrogen receptor entry|polymorphism:Genetic variations in ESR1 are correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density| disrutption of bone microarchitecture| and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.|PTM:Glycosylated; contains N-acetylglucosamine| probably O-linked.|PTM:Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity.|Belongs to the nuclear hormone receptor family.|Belongs to the nuclear hormone receptor family. NR3 subfamily.|Contains 1 nuclear receptor DNA-binding domain.|subunit:Interacts with SLC30A9 (By similarity). Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with NCOA3| NCOA5 and NCOA6 coactivators| leading to a strong increase of transcription of target genes. Interacts with NCOA7 in a ligand-inducible manner. Interacts with PHB2| PELP1 and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with KDM5A. Interacts with SMARD1. Interacts with HEXIM1 and MAP1S. Interacts with PBXIP1. Interaction with MUC1 is stimulated by 7 beta-estradiol (E2) and enhances ERS1-mediated transcription. Interacts with DNTTIP2| FAM120B and UIMC1. Interacts with isoform 4 of TXNRD1. Interacts with MLL2. Interacts with ATAD2 and this interaction is enhanced by estradiol.|