85-6388-32　CI072 Rabbit Polyclonal Antibody 100ul　BT-AP07797

特徴

• 背景：The protein encoded by this gene plays an important role in the regulation of endosomal trafficking| and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778| 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA| and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms.

仕様

• サイズ：100ul
• 抗原：Synthesized peptide derived from human CI072
• 免疫動物：Rabbit
• 交差性：Human, Mouse, Rat
• 適用：WB
• クラス：IgG
• クロナリティ：Polyclonal
• 濃度：1 mg/ml
• 別名：CI072
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