85-6362-18　LIMK-2（Phospho Thr505） Polyclonal Antibody 20ul　BT-AP06917

特徴

• 背景：There are approximately 40 known eukaryotic LIM proteins| so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA| the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK| a downstream effector of Rho| and the encoded protein| in turn| phosphorylates cofilin| inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.

仕様

• サイズ：20ul
• 抗原：Synthesized phospho-peptide around the phosphorylation site of human LIMK-2 (phospho Thr505)
• 免疫動物：Rabbit
• 交差性：Human, Mouse, Rat
• 適用：WB, IHC-p, IF, ICC, ELISA
• クラス：IgG
• クロナリティ：Polyclonal
• 濃度：1 mg/ml
• 別名：LIM domain kinase 2; LIMK2; LIM domain kinase 2; LIMK-2
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