85-6362-13　c-Myc（Phospho Thr358） Polyclonal Antibody 50ul　BT-AP06915

特徴

• 背景：The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.

仕様

• サイズ：50ul
• 抗原：The antiserum was produced against synthesized peptide derived from human Myc around the phosphorylation site of Thr358. AA range:325-374
• 免疫動物：Rabbit
• 交差性：Human, Mouse, Rat
• 適用：IHC-p, IF, IP, ELISA
• クラス：IgG
• クロナリティ：Polyclonal
• 濃度：1 mg/ml
• 別名：Myc proto-oncogene protein; MYC; BHLHE39; Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64
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