85-6361-10　PAF-R Polyclonal Antibody 50ul　BT-AP06881

特徴

• 背景：PTAFR (platelet activating factor receptor) encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.

仕様

• サイズ：50ul
• 抗原：The antiserum was produced against synthesized peptide derived from human PTAFR. AA range:194-243
• 免疫動物：Rabbit
• 交差性：Human;Mouse;Rat
• 適用：IF, ELISA
• クラス：IgG
• クロナリティ：Polyclonal
• 濃度：1 mg/ml
• 別名：PTAFR; PAFR; Platelet-activating factor receptor; PAF-R; PAFr
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